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VSL#3® DS Powder

900 Billion CFU
Probiotics are measured in colony forming units (CFU), which indicate the number of viable cells. To put it simply, labeled CFU indicates the potency of a probiotic product.

The #1 gastroenterologist-recommended multi-strain probiotics brand†

VSL#3® DS powder is a gold standard in probiotics – trusted by healthcare professionals and patients for the dietary management of GI conditions and to support microbiota balance and digestive well-being.

  • Stored and shipped cold to preserve potency
  • 8 complementary probiotic strains from 3 genera
  • Formulated for the dietary management of ulcerative colitis and pouchitis
Free Shipping on capsule multipacks, powders or any order over $101. *Only applies to the continental U.S. for VSL#3®. Orders to Alaska and Hawaii are subject to additional shipping charges. VSL4™ Gut and VSL#3® ship separately.
HSA/FSA-Eligible with Learn How

More Than a Probiotic.A Powerful Medical Food.

Pioneers in Probiotics.Leaders in Gut Health.

VSL#3® is an ultra-high-potency probiotic medical food — and the #1 gastroenterologist-recommended multi-strain probiotics brand.† Developed for people with serious gastrointestinal conditions, it’s trusted by healthcare professionals and customers alike for its scientific foundation, clinical credibility, and unwavering quality.

Built on Science.Proven in Practice.

Driven by research — not marketing trends — VSL#3® is trusted in clinical care for the dietary management of specific gastrointestinal conditions. It continues to set the standard for potency, consistency, and reliability in probiotic therapy.

Ultra-High-Potency.Guaranteed.

VSL#3® products deliver between 112.5 billion and 900 billion live bacteria per serving, depending on the formulation. Unlike many probiotics that only promise potency at the time of manufacture, VSL#3® guarantees potency through expiration when stored as directed.

Clinically Researched Formulas.Real-World Results.

Each VSL#3® product combines 8 well-characterized probiotic strains from 3 genera to help maintain a balanced intestinal microbiota and support digestive health. The VSL#3® family is specially designed for the dietary management of irritable bowel syndrome (IBS), ulcerative colitis (UC), and pouchitis.

Pioneers in Probiotics.Leaders in Gut Health.

VSL#3® is an ultra-high-potency probiotic medical food — and the #1 gastroenterologist-recommended multi-strain probiotics brand.† Developed for people with serious gastrointestinal conditions, it’s trusted by healthcare professionals and customers alike for its scientific foundation, clinical credibility, and unwavering quality.

Built on Science.Proven in Practice.

Driven by research — not marketing trends — VSL#3® is trusted in clinical care for the dietary management of specific gastrointestinal conditions. It continues to set the standard for potency, consistency, and reliability in probiotic therapy.

Ultra-High-Potency.Guaranteed.

VSL#3® products deliver between 112.5 billion and 900 billion live bacteria per serving, depending on the formulation. Unlike many probiotics that only promise potency at the time of manufacture, VSL#3® guarantees potency through expiration when stored as directed.

Clinically Researched Formulas.Real-World Results.

Each VSL#3® product combines 8 well-characterized probiotic strains from 3 genera to help maintain a balanced intestinal microbiota and support digestive health. The VSL#3® family is specially designed for the dietary management of irritable bowel syndrome (IBS), ulcerative colitis (UC), and pouchitis.

Why Doctors Trust VSL#3®

"The best product for IBD. I strongly recommend VSL#3®."

Dr. Victor Gallo

Garden City Colon and Rectal Surgery Practice - Garden City, NY

"I recommend VSL#3® for maintenance of a healthy gut microbiome."

Dr. George Barret MD

Founder and Chief of Gastroenterology Beth Israel Deaconess Hospital - Milton, MA

"I've had great success in using VSL#3® post colonoscopy, and especially so in my IBS and UC patients."

Dr. William Andy Shaver MD

Gastroenterologist - Lubbock, TX

VSL#3® Is Scientifically Formulated For The Dietary Management of IBS

Doctor Recommended

In a 2002 survey of gastroenterologists, 93% reported that IBS patients were satisfied with VSL#3.¹

The most frequently observed benefits:

  • Less bloating
  • Reduced pain
  • Better stool consistency and frequency
  • Overall symptom improvement

Clinically Studied and FODMAP Friendly Certified for the Dietary Management of IBS

In a 2021 clinical study, VSL#3® showed outcomes comparable to those achieved with a low FODMAP diet² — a commonly recommended but restrictive approach. Because VSL#3® is certified FODMAP Friendly, it can also be used alongside a low FODMAP diet for flexible dietary management.

1. Data on file 2. Ankerson L, et al. J Med Internet Res. 2021; 23(12): e30291.

It’s What’s on the Inside

Our unique 8-strain formulation is designed so each strain complements the others, helping maintain a balanced gut microbiota. Billions of live, beneficial bacteria work together to support digestive health.

Bifidobacterium

Bifidobacterium breve, Bifidobacterium lactis (previously classified as B. infantis), Bifidobacterium lactis (previously classified as B. longum)

Lactobacillus

Lactobacillus acidophilus, Lactobacillus helveticus (previously classified as L. delbrueckii subsp. bulgaricus), Lactobacillus paracasei, Lactobacillus plantarum

Streptococcus

Streptococcus thermophilus

VSL#3® DS Powder:Clean Ingredients. Verified Quality.

Free From Common Irritants:

  • Dairy-Free
  • Gluten-Free
  • Soy-Free
  • Nut-Free
  • No GMOs
  • Vegan

Certified for Peace of Mind:

  • FODMAP Friendly Approved
  • Halal Certified
  • Kosher Certified

Shipped Cold for Maximum Potency

VSL#3® is shipped cold from our facility to your door to help preserve potency and ensure live probiotics arrive active and effective. Every order is packaged in recyclable, insulated materials with reusable ice packs to maintain optimal temperature control and reduce waste.

Refrigerated Supply Chain:

Cold from production to delivery.

ClimaCell® Packaging:

Sustainably insulated and 100% curbside recyclable.

Strain Potency Preserved:

Live probiotics that stay active through expiration when stored as directed.

Shipped Cold for Maximum Potency

FAQs

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