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VSL#3^® Capsules

Name: VSL#3® Capsules
Brand: vsl3.com
SKU: 860009487314
Price: 65.95 USD
Availability: InStock

112.5 Billion CFU

Probiotics are measured in colony forming units (CFU), which indicate the number of viable cells. To put it simply, labeled CFU indicates the potency of a probiotic product.

The #1 gastroenterologist-recommended multi-strain probiotics brand^{^†}

VSL#3^® capsules are a gold standard in probiotics – trusted by healthcare professionals and patients for the dietary management of GI conditions and to support microbiota balance and digestive well-being.

Stored and shipped cold to preserve potency
8 complementary probiotic strains from 3 genera
Formulated for the dietary management of IBS and ulcerative colitis

Benefits

Clinically supported: Backed by scientific research and trusted by healthcare professionals.
Ultra-high-potency, multi-strain blend: 112.5 billion CFU per capsule from 8 complementary probiotic strains to help maintain a balanced intestinal microbiota.
Refrigerated to preserve potency: Stored and shipped cold to ensure live cultures stay potent throughout shelf life.
Precisely manufactured: Produced under GMP-certified conditions, free from dairy, gluten, and other common irritants.

How to Use

Typical adult dosage is 1–2 capsules up to 4 times daily, or as directed by a physician.
Swallow whole or mix into a non-carbonated cold beverage or food. Avoid consuming with hot foods or drinks, as heat may reduce probiotic viability.
Consistent use for several weeks may be needed to support microbiota balance.
For more information on how to take VSL#3^® for the dietary management of certain GI conditions, please see the VSL#3^® Product Information Sheet.
VSL#3^® is a medical food intended to be used under medical supervision.

Ingredients

Probiotic strains: Streptococcus thermophilus, Bifidobacterium breve, Bifidobacterium lactis (previously classified as B. longum), Bifidobacterium lactis (previously classified as B. infantis), Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus helveticus (previously classified as L. delbrueckii subsp. bulgaricus)
Other ingredients: Vegetal capsule (hydroxypropyl methylcellulose), cornstarch, magnesium stearate, silicon dioxide, stearic acid, microcrystalline cellulose.

Shipping

VSL#3^® generally ships Monday through Thursday morning. Transit time for most orders is 1-2 days, depending on your location. VSL#3^® may deliver on Saturdays. We ship our products to the continental US, Hawaii, and Alaska.
VSL#3^® is packaged in recyclable, insulated materials with reusable ice packs for temperature control and sustainability. If refrigeration isn’t immediately available, VSL#3^® remains stable for up to 14 days at room temperature.
VSL4^® and VSL#3^® products ship separately.
Learn more about shipping and handling

More Than a Probiotic.A Powerful Medical Food.

Pioneers in Probiotics.Leaders in Gut Health.

VSL#3^® is an ultra-high-potency probiotic medical food — and the #1 gastroenterologist-recommended multi-strain probiotics brand.^† Developed for people with serious gastrointestinal conditions, it’s trusted by healthcare professionals and customers alike for its scientific foundation, clinical credibility, and unwavering quality.

Built on Science.Proven in Practice.

Driven by research — not marketing trends — VSL#3^® is trusted in clinical care for the dietary management of specific gastrointestinal conditions. It continues to set the standard for potency, consistency, and reliability in probiotic therapy.

Ultra-High-Potency.Guaranteed.

VSL#3^® products deliver between 112.5 billion and 900 billion live bacteria per serving, depending on the formulation. Unlike many probiotics that only promise potency at the time of manufacture, VSL#3^® guarantees potency through expiration when stored as directed.

Clinically Researched Formulas.Real-World Results.

Each VSL#3^® product combines 8 well-characterized probiotic strains from 3 genera to help maintain a balanced intestinal microbiota and support digestive health. The VSL#3^® family is specially designed for the dietary management of irritable bowel syndrome (IBS), ulcerative colitis (UC), and pouchitis.

Pioneers in Probiotics.Leaders in Gut Health.

Built on Science.Proven in Practice.

Ultra-High-Potency.Guaranteed.

Clinically Researched Formulas.Real-World Results.

Why Doctors Trust VSL#3®

"The best product for IBD. I strongly recommend VSL#3®."

Dr. Victor Gallo

Garden City Colon and Rectal Surgery Practice - Garden City, NY

"I recommend VSL#3® for maintenance of a healthy gut microbiome."

Dr. George Barret MD

Founder and Chief of Gastroenterology Beth Israel Deaconess Hospital - Milton, MA

"I've had great success in using VSL#3® post colonoscopy, and especially so in my IBS and UC patients."

Dr. William Andy Shaver MD

Gastroenterologist - Lubbock, TX

VSL#3^® Is Scientifically Formulated For The Dietary Management of IBS

Doctor Recommended

In a 2002 survey of gastroenterologists, 93% reported that IBS patients were satisfied with VSL#3.¹

The most frequently observed benefits:

Less bloating
Reduced pain
Better stool consistency and frequency
Overall symptom improvement

Clinically Studied and FODMAP Friendly Certified for the Dietary Management of IBS

In a 2021 clinical study, VSL#3^® showed outcomes comparable to those achieved with a low FODMAP diet² — a commonly recommended but restrictive approach. Because VSL#3^® is certified FODMAP Friendly, it can also be used alongside a low FODMAP diet for flexible dietary management.

1. Data on file 2. Ankerson L, et al. J Med Internet Res. 2021; 23(12): e30291.

It’s What’s on the Inside

Our unique 8-strain formulation is designed so each strain complements the others, helping maintain a balanced gut microbiota. Billions of live, beneficial bacteria work together to support digestive health.

Bifidobacterium breve, Bifidobacterium lactis (previously classified as B. infantis), Bifidobacterium lactis (previously classified as B. longum)

Lactobacillus acidophilus, Lactobacillus helveticus (previously classified as L. delbrueckii subsp. bulgaricus), Lactobacillus paracasei, Lactobacillus plantarum

Streptococcus thermophilus

The #1 Gastroenterologist-Recommended Multi-Strain Probiotics Brand^{^†}

Trusted by healthcare professionals and millions of customers worldwide, VSL#3^® is a gold standard in multi-strain probiotics — recommended by experts for quality, consistency, and proven performance.

VSL#3^® Capsules:Clean Ingredients. Verified Quality.

Free From Common Irritants:

Dairy-Free
Gluten-Free
Soy-Free
Nut-Free
No GMOs
Vegan

Certified for Peace of Mind:

FODMAP Friendly Certified
Halal Certified
Kosher Certified

Shipped Cold for Maximum Potency

VSL#3® is shipped cold from our facility to your door to help preserve potency and ensure live probiotics arrive active and effective. Every order is packaged in recyclable, insulated materials with reusable ice packs to maintain optimal temperature control and reduce waste.

Refrigerated Supply Chain:

Cold from production to delivery.

ClimaCell® Packaging:

Sustainably insulated and 100% curbside recyclable.

Strain Potency Preserved:

Live probiotics that stay active through expiration when stored as directed.

FAQs

What is VSL#3^®?

VSL#3^® is an ultra-high-potency probiotic medical food intended for the dietary management of irritable bowel syndrome (IBS), ulcerative colitis (UC), and an ileal pouch (pouchitis).

How should I store VSL#3^®?

VSL#3^® should be stored under refrigeration at 36–46°F (2–8°C) to preserve potency. It can remain at room temperature for up to 2 weeks without reducing effectiveness.

What is a Medical Food?

Medical foods are formulated for the dietary management of diseases or conditions with distinctive nutritional needs that cannot be met by diet alone. Unlike dietary supplements, medical foods are intended for use under a healthcare provider's supervision.

How does VSL#3^® compare to a Low FODMAP diet for IBS management?

In a 2021 clinical study, VSL#3^® demonstrated dietary management outcomes in people with IBS comparable to those achieved with a low FODMAP diet¹ — a commonly recommended but restrictive approach. Because VSL#3^® is certified FODMAP Friendly, it can also be used alongside a low FODMAP diet for flexible dietary management.

1Ankerson L, et al. J Med Internet Res. 2021; 23(12): e30291.

How are VSL#3^® and VSL4^® Gut different?

Although both products contain the same 8 probiotic strains, they are formulated and labeled for different purposes. VSL#3^® is a refrigerated, ultra-high-potency probiotic medical food for the dietary management of specific GI conditions. VSL4^® Gut is a probiotic supplement designed to support digestive comfort, regularity, and overall gut health.*

VSL#3® Capsules

More Than a Probiotic.A Powerful Medical Food.

Pioneers in Probiotics.Leaders in Gut Health.

Built on Science.Proven in Practice.

Ultra-High-Potency.Guaranteed.

Clinically Researched Formulas.Real-World Results.

Pioneers in Probiotics.Leaders in Gut Health.

Built on Science.Proven in Practice.

Ultra-High-Potency.Guaranteed.

Clinically Researched Formulas.Real-World Results.

Why Doctors Trust VSL#3®

VSL#3® Is Scientifically Formulated For The Dietary Management of IBS

Doctor Recommended

Clinically Studied and FODMAP Friendly Certified for the Dietary Management of IBS

It’s What’s on the Inside

Bifidobacterium

Lactobacillus

Streptococcus

The #1 Gastroenterologist-Recommended Multi-Strain Probiotics Brand†

VSL#3® Capsules:Clean Ingredients. Verified Quality.

Shipped Cold for Maximum Potency

FAQs

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VSL#3^® Capsules

VSL#3^® Is Scientifically Formulated For The Dietary Management of IBS

The #1 Gastroenterologist-Recommended Multi-Strain Probiotics Brand^{^†}

VSL#3^® Capsules:Clean Ingredients. Verified Quality.