Cyber Monday Starts Now: Save 15% off site wide!

Thanksgiving Shipping Notice: Shipping paused from Nov 26th - 30th.

Save More with Subscriptions & Multipacks!

FREE SHIPPING on Multipacks, Powders & Orders $101+ (Continental U.S. only)

Shop All VSL® Probiotics

Shop All VSL® Probiotics

Probiotic Solutions for Every Body — Backed by Science

Explore precision-formulated probiotics designed to support digestive balance, feminine wellness, and specialized clinical care.

 

VSL#3®VSL4®Gut HealthWomen’s Health

VSL#3®: Medical Food for Advanced GI Management

Advanced GI Management

⎷ The #1 gastroenterologist-recommended multi-strain probiotics brand†

⎷ Ultra-high-potency probiotic medical food with eight clinically studied strains

⎷ Formulated for the dietary management of specific gastrointestinal conditions

VSL#3® Capsules
Best Seller
Sale
VSL#3® Capsules

For the dietary management of IBS and UC

  • 112.5 Billion CFU
  • Probiotic Medical Food
  • Refrigerated
From$131.90 $59.36
Shop Now
VSL#3® Powder
Sale
VSL#3® Powder

For the dietary management of IBS, UC, and pouchitis

  • 450 Billion CFU
  • Probiotic Medical Food
  • Refrigerated
From$225.90 $101.66
Shop Now
VSL#3® DS Powder
VSL#3® DS Powder

For the dietary management of UC and pouchitis

  • 900 Billion CFU
  • Probiotic Medical Food
  • Refrigerated
From $142.16
Shop Now

VSL4®: Targeted Probiotics for Everyday Balance

Everyday Wellness

⎷ Precision-formulated probiotics for daily digestive and feminine wellness*

⎷ Clinically informed formulas designed to support microbiome diversity and immune health*

⎷ Made for modern life — convenient, shelf-stable, and backed by science

VSL4® Gut Capsules
Sale
VSL4® Gut Capsules

Supports digestive balance, regularity, and overall gut health.*

  • 30 Billion CFU
  • Probiotic Supplement
  • Shelf-stable
From$69.90 $31.46
Shop Now
VSL4® Vaginal Health
NEW!
VSL4® Vaginal Health

Supports vaginal microbiota balance, normal yeast and pH levels, and urinary tract health.*

  • 10 Billion CFU, Prebiotic Fiber, Essential Vitamins, Cranberry Extract
  • Probiotic Supplement
  • Shelf-stable
From $26.96
Shop Now

Gut Health: From Advanced GI Management to Daily Digestive Wellness

Gut Health at Every Level

⎷ VSL#3®: Proven medical food for the dietary management of complex GI conditions

⎷ VSL4® Gut: Probiotic supplement to support comfort, balance, and digestive well-being*

⎷ Products made to support gut health at every level

VSL#3® Capsules
Best Seller
Sale
VSL#3® Capsules

For the dietary management of IBS and UC

  • 112.5 Billion CFU
  • Probiotic Medical Food
  • Refrigerated
From$131.90 $59.36
Shop Now
VSL#3® Powder
Sale
VSL#3® Powder

For the dietary management of IBS, UC, and pouchitis

  • 450 Billion CFU
  • Probiotic Medical Food
  • Refrigerated
From$225.90 $101.66
Shop Now
VSL4® Gut Capsules
Sale
VSL4® Gut Capsules

Supports digestive balance, regularity, and overall gut health.*

  • 30 Billion CFU
  • Probiotic Supplement
  • Shelf-stable
From$69.90 $31.46
Shop Now

Women’s Health: Inner Balance and Everyday Confidence

Intimate Care and Confidence

⎷ Promotes a healthy vaginal microbiome, pH, and odor*

⎷ Supports natural defenses for vaginal and urinary tract health*

⎷ 4-in-1 formula with probiotics, a prebiotic, vitamins, and cranberry extract

VSL4® Vaginal Health
NEW!
VSL4® Vaginal Health

Supports vaginal microbiota balance, normal yeast and pH levels, and urinary tract health.*

  • 10 Billion CFU, Prebiotic Fiber, Essential Vitamins, Cranberry Extract
  • Probiotic Supplement
  • Shelf-stable
From $26.96
Shop Now

Science Over Hype. Purpose Over Promises.

Built on the legacy of VSL#3® — a probiotic trusted by healthcare professionals and recognized for its scientific rigor — VSL® Probiotics continues to advance microbiome science through targeted, high-quality formulations that support both clinical dietary management and everyday wellness.
For us, potency isn’t a number — it’s a principle. Every VSL® Probiotics formulation is developed with meaningful levels of live bacteria, manufactured under controlled conditions, and verified to maintain the labeled CFU count through expiration when stored as recommended. Potency matters because probiotic function depends on both the quantity and vitality of live organisms that reach the gut. Even modest loss over time can affect performance, which is why every VSL® Probiotics product is designed and tested to deliver consistent strength from first dose to last.

Committed to Potency

Potent probiotic formulations guaranteed to maintain labeled CFU counts through expiration.

For probiotics to work, live microorganisms must survive both storage and digestion to reach the gut intact. Every VSL® Probiotics formulation is developed with this in mind — combining carefully selected strains, stability-enhancing formulation design, and packaging to maintain viability from manufacturing through expiration.VSL#3® is maintained under strict cold-chain conditions — refrigerated throughout production, storage, and shipping — to help preserve live strains at their intended strength. VSL4® products are shelf-stable and formulated with acid-resistant capsules that help protect probiotic bacteria until they reach the intestinal tract.

Designed for Viability

Carefully designed formulations that help safeguard live bacteria from production to delivery.

Our formulations are grounded in science. Each strain is selected for its documented characteristics and ability to contribute meaningfully to a balanced microbiome. This approach draws on years of probiotic research — building on well-studied formulations and evidence-backed strains to create products designed for specific microbiome needs.Across the VSL® Probiotics family, every formulation follows the same principle: science guides each step, from strain selection to finished product. This consistent, evidence-based process ensures reliability and quality across the brand’s entire portfolio.

Science-Led Strain Selection

Thoughtfully formulated with complementary probiotic strains chosen for function and purpose.

VSL® Probiotics builds on the legacy of VSL#3® — a formulation long trusted by healthcare professionals for its quality and reliability. That foundation continues to guide how we develop every product in the VSL® Probiotics family. Our focus remains the same: to create formulations grounded in evidence, crafted with precision, and respected for their consistency — not driven by trends, but by trust earned through experience.

A Legacy of Expertise

A probiotic heritage recognized for its consistency, credibility, and professional trust.

Clean Ingredients. Trusted Standards.

We believe what's not in your probiotic is just as important as what is.

Dairy Free

Gluten-Free

No GMOs

Soy-Free

The VSL® Probiotics Difference

Medical Foods & Supplements

From medical foods formulated for the dietary management of GI conditions to supplements for daily wellness, VSL® Probiotics is made to the highest standards of quality and consistency.

Proven Potency

Up to 900 billion live bacteria per serving — verified to maintain labeled CFU counts through expiration when stored as recommended.

Evidence-Based Formulations

Formulated with probiotic strains and combinations supported by published research and guided by microbiome science.

Trusted by Professionals

Rooted in the heritage of VSL#3®—a probiotic trusted by healthcare professionals—VSL® Probiotics carries that same dedication to quality and research into every new formulation.

Medical Foods & Supplements

From medical foods formulated for the dietary management of GI conditions to supplements for daily wellness, VSL® Probiotics is made to the highest standards of quality and consistency.

Proven Potency

Up to 900 billion live bacteria per serving — verified to maintain labeled CFU counts through expiration when stored as recommended.

Evidence-Based Formulations

Formulated with probiotic strains and combinations supported by published research and guided by microbiome science.

Trusted by Professionals

Rooted in the heritage of VSL#3®—a probiotic trusted by healthcare professionals—VSL® Probiotics carries that same dedication to quality and research into every new formulation.

Smart Ways to Save

Subscribe & Save 10%

Stay on track with your easiest way to save.

Bundle & Save up to 15%

The more you buy, the more you save.

Use HSA/FSA Funds

Pay with pre-tax dollars on qualified purchases.

What Our Customers Say