Our Black Friday Sale is Here! New customers save 15% on VSL#3® (up to $15) with code 15VSL3 and 30% on VSL4™ GUT with code 30VSL4.

Happy Thanksgiving! To ensure delivery during Thanksgiving week, please place your order by noon EST on 11/25.

The #1 Gastroenterologist-Recommended

The #1 Gastroenterologist-Recommended Multi-Strain Probiotics Brand†

Looking for the dietary management of IBS, UC or pouchitis? Or seeking support for regularity and digestion?* No worries, we can help!

†VSL#3®, ProVoice® Surveys

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Multi-Strain Probiotics Brand†

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Find The Product That's Right For You

VSL4™ Gut Capsules
NEW!
Sale
VSL4™ Gut Capsules
$69.90 $31.46
Probiotic Supplement
30 Billion CFU per capsule
  • Promotes regularity, digestion and general gut health*
  • 30 Capsules
  • Shelf-stable
VSL#3® Capsules
Best Seller
Sale
VSL#3® Capsules
$131.90 $59.36
Probiotic Medical Food
112.5 Billion CFU per capsule
  • For the dietary management of IBS and UC
  • 60 Capsules
  • Refrigerated
VSL#3® Powder
Sale
VSL#3® Powder
$225.90 $101.66
Probiotic Medical Food
450 Billion CFU per packet
  • For the dietary management of IBS, UC and pouchitis
  • 30 Packets
  • Refrigerated
VSL#3® DS Powder
VSL#3® DS Powder
$142.16
Probiotic Medical Food
900 Billion CFU per packet
  • For the dietary management of UC and pouchitis
  • 20 Packets
  • Refrigerated

Suffering from

Abdominal Pain
Bloating
Constipation
Diarrhea
Fatigue
Gas

these occasional symptoms?

Suffering from

these occasional symptoms?

Abdominal Pain
Bloating
Constipation
Diarrhea
Fatigue
Gas
Abdominal Pain
Bloating
Constipation
Diarrhea
Fatigue
Gas

Serious Gut Issues Or Everyday Wellness?

Whatever your need, our potent probiotics are scientifically formulated to support your digestive well-being:

  • VSL#3® is a probiotic medical food intended for the dietary management of IBS, UC and pouchitis.
  • VSL4™ Gut is a daily probiotic supplement formulated to help you Have a Good Gut Feeling™ by supporting regularity, digestion and general gut health.*

VSL#3®

Intended for the dietary management of IBS, UC, and pouchitis

VSL4™ Gut

Promotes regularity and healthy digestion*

The #1 gastroenterologist-recommended multi-strain probiotics brand†
From the makers of VSL#3®
Eight complementary strains from three different genera
Features the same eight strains as VSL#3®
Highest-Potencies (112.5B to 900B CFU)
Potent (30B CFU)
Refrigerated
Shelf-stable
Probiotic Medical Food
Daily Probiotic Supplement

VSL#3®

Intended for the dietary management of IBS, UC, and pouchitis

The #1 gastroenterologist-recommended multi-strain probiotics brand†
Eight complementary strains from three different genera
Highest-Potencies (112.5B to 900B CFU)
Refrigerated
Probiotic Medical Food

VSL4™ Gut

Promotes regularity and healthy digestion*

From the makers of VSL#3®
Features the same eight strains as VSL#3®
Potent (30B CFU)
Shelf-stable
Daily Probiotic Supplement

We Are Pros In Probiotics

We've been making powerful, multi-strain probiotics for over twenty years, and our products are available in over 40 countries. Our experience has helped us gain the expertise needed to provide you with the right gut health solutions. Learn more about what makes our products special.

  • Potency, Guaranteed

    • VSL#3® offers some of the highest-potency probiotics available, ranging from 112.5 billion to 900 billion CFU per serving.

    VSL4™ Gut is also potent, with 30 billion CFU per capsule.

    While some probiotic brands quote their potency based on the bacteria present at the date of manufacture, we quote the CFU count of our products at expiration if stored under recommended conditions. This means you get more of what you pay for.

    Learn more...

  • Eight-Strain Diversity

    • VSL#3® contains eight complementary strains from three different genera and has been shown to restore microbial imbalances in the GI tract when modifications to normal diet are insufficient.

    VSL4™ Gut features the same eight strains found in VSL#3® but in a shelf-stable formula.

    Learn more...

  • Shipped To Survive, Made To Thrive

    • To ensure the potency of VSL#3®, we use a “cold chain” supply chain. We then ship VSL#3® to you in thermally lined, refrigerated shipping boxes. These measures ensure that our bacteria arrive alive and ready to colonize your gut. 

    VSL4™ Gut has been formulated to be shelf-stable and still deliver the 30 billion CFU promised on its label. And its delayed-release, acid-resistant capsule technology ensures a high survival rate through the digestive system.

    Learn more...

  • Highly Researched

    • VSL#3® has been the subject of more than 40 scientific publications in the last five years alone. Researchers turn to VSL#3® because of its potency, eight-strain diversity, refrigerated bacteria, and overall quality. 

    Learn more...

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Potency, Guaranteed

VSL#3® offers some of the highest-potency probiotics available, ranging from 112.5 billion to 900 billion CFU per serving.

VSL4™ Gut is also potent, with 30 billion CFU per capsule.

While some probiotic brands quote their potency based on the bacteria present at the date of manufacture, we quote the CFU count of our products at expiration if stored under recommended conditions. This means you get more of what you pay for.

Learn more...

Eight-Strain Diversity

VSL#3® contains eight complementary strains from three different genera and has been shown to restore microbial imbalances in the GI tract when modifications to normal diet are insufficient.

VSL4™ Gut features the same eight strains found in VSL#3® but in a shelf-stable formula.

Learn more...

Shipped To Survive, Made To Thrive

To ensure the potency of VSL#3®, we use a “cold chain” supply chain. We then ship VSL#3® to you in thermally lined, refrigerated shipping boxes. These measures ensure that our bacteria arrive alive and ready to colonize your gut. 

VSL4™ Gut has been formulated to be shelf-stable and still deliver the 30 billion CFU promised on its label. And its delayed-release, acid-resistant capsule technology ensures a high survival rate through the digestive system.

Learn more...

Highly Researched

VSL#3® has been the subject of more than 40 scientific publications in the last five years alone. Researchers turn to VSL#3® because of its potency, eight-strain diversity, refrigerated bacteria, and overall quality. 

Learn more...

Dairy-Free
Soy-Free
Gluten-Free
Non-GMO
Nut-Free
Vegan

Over 1,500 5-star Reviews

Finally IBS relief!

These probiotics are amazing! I suffer with IBS and these really help me. I’ve tried many brands of probiotics but these work and are worth every penny!
✓ Verified Buyer: VSL#3®

Good Gut, Almighty!

"This the best probiotic on the market. It has the highest bacteria count. It helps me a great deal with my IBS."
✓ Verified Buyer: VSL#3®

This stuff

"This stuff has been an absolute game-changer in managing my UC. G_d bless VSL#3."
✓ Verified Buyer - VSL#3®

Good stuff!

"I have used for years and love this stuff. It helps control my pouchitis."
✓ Verified Buyer: VSL#3®

Great product!

"Love VSL! significantly reduced symptoms of bloating, cramping and stool consistency."
✓ Verified Buyer: VSL#3®

The only probiotic that helps with my IBS

"I’ve tried every other probiotic and none of them works but VSL3."
✓ Verified Buyer: VSL#3®

FAQ