How VSL#3® Provides Probiotic Support In Irritable Bowel Syndrome (IBS)

VSL#3® contains 8 diverse probiotic strains, each with a distinct mechanism to address barrier dysfunction1-6

*Reclassified as L. helveticus
Reclassified as B. lactis.

At a Glance: See How VSL#3® Works

VSL#3® probiotic strains

A meta-analysis of 23 randomized controlled trials with a total of 1763 participants suggested probiotics containing a combination of multiple strains help preserve the mucosal barrier better than single-strain versions.11

Patients report a substantial increase in quality of life after taking VSL#3® 12

In a recent VSL#3® patient satisfaction study, where quality of life was rated on a 10-point scale (with 10 being the best):

  • Before taking VSL#3®, 13% of patients reported a quality of life of 8 or higher
  • After taking VSL#3®, 75% of patients reported a quality of life of 8 or higher

The consensus document from the 4th Triennial Yale/Harvard Workshop on Probiotics recommended VSL#3® for patients with IBS.13

Learn more about dosing and how to prescribe VSL#3®.

How to Dose VSL#3®

References: 1. Brigidi P, Vitali B, Swennen E, Bazzocchi G, Matteuzzi D. Res Microbiol. 2001;152(8):735-741. 2. Biblioni R, Fedorak RN, Tannock GW, et al. Am J Gastroenterol. 2005;100(7):1539-1546. 3. Bermudez-Brito M, Plaza-Díaz J, Muñoz-Quezada S, Gómez-Llorente C, Gil A. Ann Nutr Metab. 2012;61(2):160-174. 4. Fedorak RN. J Clin Gastroenterol. 2008;42(suppl 3 [pt 1]):S111-S115. 5. Dai C, Zhao DH, Jiang M. Int J Mol Med. 2012;29(2):202-208. 6. Lammers KM, Brigidi P, Vitali B, et al. FEMS Immunol Med Microbiol. 2003;38(2):165-172. 7. VSL#3® Product Information. Alfasigma USA, Covington, LA. 2017. 8. Cornick S, Tawiah A, Chadee K. Tissue Barriers. 2015;3(1-2):e982426. 9. Caballero-Franco C, Keller K, De Simone C, Chadee K. Am J Physiol Gastrointest Liver Physiol. 2007;292(1):G315-G322. 10. Distrutti E, Cipriani S, Mencarelli A, Renga B, Fiorucci S. PLoS One. 2013;8(5):e63893. 11. Shen J, Zuo Z-X, Mao A-P. Inflamm Bowel Dis. 2014;20(1):21-35. 12. Data on file, Alfasigma USA, Inc. 13. Floch MH, Walker WA, Sanders ME, et al. J Clin Gastroenterol. 2015;49(suppl1):S69-S73.

*Reclassified as L. helveticus.
Reclassified as B. lactis.

References: 1. VSL#3 Product Information Sheet. 2017. 2. Bermudez-Brito M, Plaza-Díaz J, Muñoz-Quezada S, Gómez-Llorente C, Gil A. Ann Nutr Metab. 2012;61(2):160-174. 3. Maxwell LVT, Miller MJ. Nutrients. 2011;3:613-636. 4. Hart AL, Lammers K, Brigidi P, et al. Gut. 2004;53(11):1602-1609. 5. Lammers KM, Brigidi P, Vitali B, et al. FEMS Immunol Med Microbiol. 2003;38(2):165-172. 6. Dai C, Zhao D-H, Jiang M. Int J Mol Med. 2012;29(2):202-208.